A new methodology for the synthesis of polyhydroxylated pyrrolidines using epoxysulfones is described. The synthesis of two natural glycosidase inhibitors, 1,4-dideoxy-1,4-imino-d-lyxitol and 1,4-dideoxy-1,4-imino-d-mannitol (DIM), is reported.
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Dı́ez et al. (2005) studied this question.