Catalysts get food poisoning: Conversion of the active 1-alkene hydroformylation catalyst 1 with reactive impurities in the feed, such as dienes and enones, into unreactive rhodium intermediates leads to deactivation of 1. For example, 2 is much more reactive towards 1 than the substrate and transforms it temporarily into 4 blocking the hydroformylation activity.
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Walczuk et al. (2003) studied this question.
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