Key result
Adding four criteria to conventional ECG and echo boosts familial HCM diagnostic sensitivity to 88%.
Why the study?
The diagnostic accuracy of electrocardiography and echocardiography for familial hypertrophic cardiomyopathy in children using genetic status as reference was uncertain.
Do additional minor electrocardiographic and echocardiographic criteria improve the diagnostic sensitivity for familial hypertrophic cardiomyopathy in genotyped children?
Population
35 children under 18 years from 13 families with identified mutations
Comparison
Electrocardiography and echocardiography conventional and additional criteria vs genetic status
Design
Cross-sectional analysis
Authors
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May aid pediatric HCM screening; leaves open prospective validation before practice change.
Cross-Sectional (n=35)
Do additional minor electrocardiographic and echocardiographic criteria improve the diagnostic sensitivity for familial hypertrophic cardiomyopathy in genotyped children?
Adding specific minor ECG and echocardiographic criteria significantly improves the sensitivity of diagnosing familial hypertrophic cardiomyopathy in children who are genetic carriers.
Philippe Charron (1998) conducted a cross-sectional in familial hypertrophic cardiomyopathy (n=35). Electrocardiography and echocardiography vs. Genetic status (reference criterion) was evaluated on Diagnosis of familial hypertrophic cardiomyopathy (sensitivity and specificity). Adding four criteria to conventional ECG and echocardiography increased diagnostic sensitivity for familial hypertrophic cardiomyopathy to 88% while maintaining 95% specificity.
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