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All articles of this category A total synthesis of the non-opiate antinociceptive alkaloid (±)-epibatidine and its congeners is described, in which the key step is the reductive elimination of hydroxy function in 8a . The hydrogenolysis of 8a proceeded smoothly with retention of the configuration to afford 9a . Biological evaluation of these compounds is also included.
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Senokuchi et al. (1994) studied this question.