The investigation and management of recurrent early pregnancy loss: a Canadian Fertility and Andrology Society clinical practice guideline

This guideline defines recurrent early pregnancy loss (REPL) as two or more losses that occur before 10 weeks gestational age and includes non-consecutive and biochemical losses. Investigations should be considered on an individual basis and may include an evaluation of genetic, anatomical, endocrinological, structural and male-associated factors. Based on the findings and available resources, options for management may include preimplantation genetic testing (PGT) for aneuploidies or PGT for chromosomal structural rearrangements, progesterone supplementation and supportive care. This guideline emphasizes a personalized approach to the problem of REPL, recognizing an overall promising prognosis for this patient population and the avoidance of treatment options that have not been shown to be of benefit.