The use of inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of blood samples from rheumatoid arthritis patients on gold drug therapy is demonstrated. Flow injection allows the determination of multiple metal ions (Au, Zn and Cu) in a single injection with detection limits that are more than adequate for the analysis. Matrix effects are significant with these samples. Chromatography is also possible with ICP-MS as the detector. Examples are given of high-performance liquid chromatography of patient blood samples using size-exclusion and weak anion-exchange columns.
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Matz et al. (1989) studied this question.