The exposure conditions which produce hind limb paralysis in 10%, 50%, and 90% of mouse neonate specimens exposed to 1-MHz ultrasound at 10° C and at 1- and 16-atm hydrostatic pressure were determined for the intensity range 86–289 W/cm2. The change in the exposure duration for 50% of the specimens paralyzed resulting from pressurization to 16 atm was negligible at 86 and 144 W/cm2 but was almost a factor of 2 increase at 289 W/cm2. Pressurization suppressed the observed half-harmonic received signal at all intensities. These results suggest that cavitation may influence the production of the hind limb paralysis produced in the neonate at 1 atm and at 289 W/cm2.
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Frizzell et al. (1983) studied this question.