Summary: This minireview describes strategies for preparation of biodegradable (from polylactides, and poly(ε‐caprolactone) and from their derivatives) nano‐ and microspheres for medical applications, in particular for drug delivery. In addition to standard methods of particles' formation by emulsification of polymer solution in water‐miscible organic solvent with subsequent solvent evaporation or extraction there are described methods of particles formation by self assembly of polymer macromolecules, by dialysis of polymer solutions in organic water‐miscible solvents carried on against water and by dispersion ring‐opening polymerization of heterocyclic monomers. Strategies for encapsulation of bioactive compounds into nano‐ and microspheres are presented.
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Stanisław Słomkowski (2010) studied this question.
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