We have investigated in a thermogravitational apparatus the behavior of solutions containing macromolecular solutes and of suspensions of ultramicroscopic particles such as viruses and ribosomes. We have obtained very high separation ratios with all the solutes studied, the value of the separation being characteristic of each solution. The reproducibility of the results is good, and the dependence on the geometrical and physical parameters involved fits the predictions of the phenomenological theory. Our results prove that fractionation of very high molecular weight particles is feasible by this method, and also that the characterization of the macromolecular species and the determination of the mass and shape of the particles of the solute seem to be within the possibilities of the thermogravitational method when this is applied to very high molecular weight materials.
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Gaeta et al. (1969) studied this question.
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