Key result
T2-weighted cardiac magnetic resonance imaging has emerged as a clinically feasible and accurate non-invasive tool to quantify the myocardium at risk and myocardial salvage in myocardial infarction.
T2-weighted cardiac magnetic resonance imaging has emerged as a clinically feasible and accurate non-invasive tool to quantify the myocardium at risk and myocardial salvage after myocardial infarction.
When a thing ceases to be a subject of controversy, it ceases to be a subject of interest Occlusion of a coronary artery in the setting of myocardial infarction (MI) results in ischaemic injury of the myocardium supplied by the infarct-related artery with a subsequent acute risk of ischaemic cell death of the myocardium at risk (MAR). Rapid reperfusion of such acutely ischaemic, but yet only reversibly injured, myocardium has the potential for salvaging viable myocytes. If not timely reperfused, a wave front of irreversible injury gradually replaces the MAR.1 In recent years, visualization of the MAR has gained much attention because the capability of assessing the MAR is crucial to non-invasively determine the amount of myocardial salvage and to evaluate the efficacy of therapeutic interventions aimed at reducing myocardial damage. Of all available methods for assessing the MAR, including electrocardiography, angiographic scores (e.g. Duke jeopardy score, BARI score, and APPROACH score), contrast echocardiography, nuclear imaging methods, and cardiac computed tomography, cardiac magnetic resonance (CMR) imaging has emerged as the clinically most feasible and accurate non-invasive tool to quantify the MAR and myocardial salvage.2T2-weighted CMR imaging is sensitive to myocardial oedema, and it has been convincingly demonstrated in experimental and human studies that the area of oedema can retrospectively mark the MAR after the patient has been reperfused and stabilized.3–5 Although accurate T2-weighted CMR approaches for assessing the MAR are available and are successfully applied in clinical settings and studies, some questions have been raised regarding physiological and mechanistic assumptions underlying this application.6,7
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Eitel et al. (2014) conducted an editorial in Myocardial infarction. T2-weighted cardiac magnetic resonance (CMR) imaging was evaluated. T2-weighted cardiac magnetic resonance imaging has emerged as a clinically feasible and accurate non-invasive tool to quantify the myocardium at risk and myocardial salvage in myocardial infarction.
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