Computational modeling study demonstrates robust dose-response characterization for insoluble engineered nanomaterials, indicating improved translation from cell cultures to living systems.
Dose assessment is essential for understanding the mechanisms triggering nanomaterial toxicity in vitro and for meaningful translations to in vivo. We propose a novel computational approach for improving the accuracy of biological dose-response characterization, demonstrating its robustness for insoluble Engineered Nanomaterials (ENMs).
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Botte et al. (2021) studied this question.
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