Use of Labile Precursors for the Generation of Hyperpolarized Molecules from Hydrogenation with Parahydrogen and Aqueous‐Phase Extraction

Hyperpolarization using parahydrogen can be more efficient when the reaction is carried out on a precursor that is then quickly transformed into the desired probe. The procedure was tested with [1-13C]succinate prepared from hydrogenation with parahydrogen of maleic anhydride followed by hydrolysis. This method also allows the catalyst to be removed without polarization loss.