Interactions between the hippocampus, prefrontal cortex, and amygdala support complex learning and memory

One of the guiding principles of memory research in the preceding decades is multiple memory systems theory, which links specific task demands to specific anatomical structures and circuits that are thought to act orthogonally with respect to each other. We argue that this view does not capture the nature of learning and memory when any degree of complexity is introduced. In most situations, memory requires interactions between these circuits and they can act in a facilitative manner to generate adaptive behavior.