Key result
Nonalcoholic fatty liver disease was strongly associated with the presence of nonalcoholic fatty pancreas disease (OR 16.76, P=0.005), alongside increasing triglycerides and decreasing ApoA-1.
Why the study?
Early assessment of pancreatic fat infiltration has an increasing role in managing metabolic dysregulation and preventing pancreatic complications, but its prevalence and associated factors require evaluation.
Observational (n=4,704)
No
Odds Ratio: 16.76
p-value: p=0.005
Nonalcoholic fatty pancreas disease is strongly associated with nonalcoholic fatty liver disease, hypertriglyceridemia, and decreased apolipoprotein A-1 in a Chinese inpatient population.
Background and Objectives: The positive energy balance between caloric intake and caloric output increasing storage of triglycerides (TG) in adipocytes has made nonalcoholic fatty liver disease (NAFLD) one of the major public health problems in China. Excessive lipid deposition in the pancreas is referred to as nonalcoholic fatty pancreas disease (NAFPD). Early assessment of pancreatic fat infiltration will have an increasing role in the clinical management of the metabolic dysregulation and prevention pancreatic complications. Subjects and Methods: We retrospectively collected data of inpatients with NAFPD from EUS database between September 2012 and August 2020 at our endoscopic center. The prevalence of NAFPD and factors associated with its development were statistically analyzed. The echogenicity of the pancreas was compared to that of the left renal cortex during the EUS examination by using an existing criterion. Results: Four thousand, seven hundred and four consecutive individuals underwent EUS were enrolled. The prevalence of NAFPD was 1.2% (57/4704) . Factors independently associated with NAFPD on multivariate analysis were increasing TG (odds ratios [OR] 4.65, P = 0.014), NAFLD (OR 16.76, P = 0.005) and decreasing apolipoprotein A-1 (OR 0.002, P = 0.0127). We found no association between NAFPD and age, sex, total cholesterol or hypertension. Conclusions: We found a meaningful relationship between NAFLD, dyslipidemia, and NAFPD in Chinese. We hypothesized that NAFPD was strongly correlated with ectopic fat deposition and its related abnormalities of lipid metabolism. Early diagnosis of NAFLD provides opportunities to control the progression of NAFPD.
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Chen et al. (2022) conducted an observational in Nonalcoholic fatty pancreas disease (NAFPD) (n=4,704). Nonalcoholic fatty liver disease (NAFLD) was evaluated on Nonalcoholic fatty pancreas disease (NAFPD) (OR 16.76, p=0.005). Nonalcoholic fatty liver disease was strongly associated with the presence of nonalcoholic fatty pancreas disease (OR 16.76, P=0.005), alongside increasing triglycerides and decreasing ApoA-1.
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