Diethyl‐ and Di‐n‐Butyltin(IV) 3‐Amino‐4‐Methylbenzoates: Synthesis, Spectroscopic Characterization and in Vitro Antitumor Activity

Diethyl‐ and di‐n‐butyltin(IV) oxides react with 3‐amino‐4‐methylbenzoic acid in a 1:2 (a) and 1:1 (b) molar ratio to yield dialkyltin compounds of the types R2Sn[O2C‐C6H3‐3‐NH2‐4‐CH3]2 (a) and {[R2Sn(O2C‐C6H3‐3‐NH2‐4‐CH3)]2O}2 (b). The compounds obtained were characterized by 1H, 13C, 119Sn NMR and by Mössbauer spectroscopy. Compound 1a was tested in vitro against two human tumor cell lines, MCF‐7, a mammary tumor, and WiDr, a colon carcinoma.