Key result
Rapid insulin sensitivity test proves sensitive and reproducible for establishing insulin dose-response curves in rats.
Why the study?
A rapid insulin sensitivity test (RIST) was recently introduced to assess insulin action in vivo, requiring a standardized operating procedure based on additional experience.
Population
Approximately 100 RIST tests in rats
Comparison
Toronto pork-beef insulin vs human insulin; insulin administration methods
Design
Technical report describing standard operating procedure
Authors
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Supports RIST refinement for rat metabolic studies; leaves open translation to clinical insulin research.
Lautt et al. (1998) studied this question. Rapid insulin sensitivity test (RIST) was evaluated on RIST index (amount of glucose required to maintain euglycemia). The rapid insulin sensitivity test (RIST) using a 5-minute insulin infusion is a sensitive and reproducible method for establishing insulin dose-response curves in rats.
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