Why the study?
Enhancing the browning ability of visceral adipose tissue is of therapeutic interest for central obesity, leading investigators to evaluate the regulatory role of miR-27b-3p in epididymal white adipose tissue browning.
Does inhibition of miR-27b-3p enhance browning of epididymal fat and improve metabolism in HFD-induced obese mice?
Population
High-fat diet induced obese mice
Comparison
Tail vein injection of antimiR-27b-3p vs control
Design
Preclinical animal study
Key result
Inhibition of miR-27b-3p enhanced the browning capacity of epididymal white adipose tissue in high-fat diet-induced obese mice, leading to reduced weight gain and improved insulin sensitivity.
Authors
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Supports miR-27b-3p inhibition in obese mice; hypothesis-generating and requires human validation before any clinical consideration.
Does inhibition of miR-27b-3p enhance browning of epididymal fat and improve metabolism in HFD-induced obese mice?
Inhibition of miR-27b-3p enhances browning of epididymal white adipose tissue, leading to weight loss and improved insulin sensitivity in a mouse model of diet-induced obesity.
Yu et al. (2019) studied High-fat diet induced obesity. antimiR-27b-3p lentivirus vs. scrambled control (scr-miR) lentivirus was evaluated on Browning capacity of epididymal white adipose tissue (eWAT) and insulin sensitivity. Inhibition of miR-27b-3p enhanced the browning capacity of epididymal white adipose tissue in high-fat diet-induced obese mice, leading to reduced weight gain and improved insulin sensitivity.