Part of the queue. Biosynthesis of the cytostatic polyketide aureothin (1) in Streptomyces thioluteus was found to involve two tailoring steps (see scheme). Mutational biosynthesis of nor-deoxyaureothin (α-2) and a hydroxylated derivative (3), together with biotransformation experiments revealed a well-defined order for the polyketide-tailoring steps. Regioselective γ-pyrone methylation was found to be the penultimate biosynthetic step prior to furan-ring formation.
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Müller et al. (2005) studied this question.
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