Characterization of bioactive compounds in defatted hempseed ( Cannabis sativa L.) by UHPLC-HRMS/MS and anti-inflammatory activity in primary human monocytes

in F03). Both, F03 and F05 significantly reduced the inflammatory competence of LPS-treated human primary monocytes, decreasing TNF-α and IL-6 gene expression and secretion. These findings indicate that in the defatted fraction of the hempseed there are a wide number of compounds with beneficial potential to prevent and treat inflammatory disorders, as well as other processes caused by oxidative stress.