The comparison of structures in the solid state and in solution by one method—NMR spectroscopy — enabled unequivocal demonstration of structural changes on dissolution of a solid compound. Thus,e.g., in the crystal the vinylogous amide (R = C6H11) investigated is E-configurated at the CC double bond; in solution a Z-form is most stable.
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Kessler et al. (1981) studied this question.
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