Key result
Stress dose steroids and an IL-1 inhibitor linked to improved cardiac function in fulminant cardiogenic shock.
Case Report (n=1)
Autoimmune polyglandular syndrome 2 can present with fulminant cardiogenic shock and myopericarditis, which may respond to VA-ECMO, steroids, and IL-1 inhibition.
Hypothesis-generating for IL-1 inhibition plus steroids in APS2 shock; larger studies needed before any practice change.
A 34-year-old man presented with acute pericarditis and a small pericardial effusion but rapidly decompensated into cardiac tamponade and fulminant cardiogenic shock, requiring venoarterial extracorporeal membrane oxygenation cannulation. He was diagnosed with autoimmune polyglandular syndrome 2 and was treated with stress dose steroids and an interleukin-1 inhibitor, with improvement in his cardiac function.
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Lee et al. (2023) conducted a case report in Recurrent Myopericarditis and Fulminant Cardiogenic Shock Due to Autoimmune Polyglandular Syndrome 2 (n=1). Stress dose steroids and an interleukin-1 inhibitor was evaluated on Improvement in cardiac function. Treatment with stress dose steroids and an interleukin-1 inhibitor led to improvement in cardiac function in a 34-year-old man with autoimmune polyglandular syndrome 2 and fulminant cardiogenic shock.
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