Purine receptor subtypes are expressed with some selectivity on different types of cells in the cardiovascular system and are possible targets for therapeutic strategies in cardiovascular diseases. The considerable efforts of the clinical biochemists working in this field is leading to a promising emergence of subtype-specific P2 ligands. This will open up new avenues for research into the physiological roles of purine receptors and their therapeutic potential.
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Ralevic et al. (2003) studied this question.