Key result
Short-term dexamethasone completely resolves reversible splenial lesion syndrome associated with encephalitis.
Why the study?
Most cases of RESLES associated with encephalitis/encephalopathy have a good prognosis, but some require intensive care or have a poor prognosis.
Does short-term steroid treatment improve neurological deterioration in a patient with RESLES associated with encephalitis/encephalopathy?
Case Report (n=1)
No
Does short-term steroid treatment improve neurological deterioration in a patient with RESLES associated with encephalitis/encephalopathy?
Short-term steroid treatment may be beneficial for neurological deterioration in patients with RESLES associated with encephalitis/encephalopathy.
RESLES in encephalitis may require intensive monitoring for rare poor outcomes; leaves open predictors of prognosis in larger cohorts.
Reversible splenial lesion syndrome (RESLES) is a complex clinicoradiological entity that has been reported to occur secondary to several disorders, including acute encephalitis/encephalopathy. On magnetic resonance imaging, it presents as reversible hyperintense signal lesions on diffusion-weighted images and hypointense on apparent diffusion coefficient images. Most case of RESLES associated with encephalitis/encephalopathy have a good prognosis, but some require intensive care or have poor prognosis. We report a case of RESLES associated with encephalitis/encephalopathy in which neurological deterioration improved after steroid treatment.
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Lim et al. (2023) conducted a case report in Reversible Splenial Lesion Syndrome (RESLES) associated with encephalitis/encephalopathy (n=1). Dexamethasone was evaluated on Clinical and radiological improvement. Short-term dexamethasone treatment led to complete clinical and radiological resolution of reversible splenial lesion syndrome associated with encephalitis/encephalopathy.
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