Solubility Enhancement of Piroxicam Using Different Concentrations of the Hydrotropic Agent Sodium Benzoate

Background: Piroxicam is a non-steroidal anti-inflammatory drug, used to alleviate inflammatory signs and symptoms.It is a potent acidic drug that presents mainly in unionized form in the stomach, thus it has a high permeability through the stomach, but poor aqueous solubility.This study, tried to explore the application of hydrotropes to improve the solubility of piroxicam by using different concentrations of the hydrotropic agent sodium benzoate.Methods: Maximum absorbance of piroxicam and its calibration curve was determined using methanol as a solvent, saturated solubility of piroxicam in distilled water and in various concentrations of sodium benzoate 5%, 10%, 15% was measured.Results: The results showed that saturated solubility of piroxicam in aqueous solutions of 5%, 10%, and 15% of sodium benzoate was 19, 53, and 89 time respectively greater than its solubility in distilled water.Conclusion: There was a clear improvement in the solubility of piroxicam with the addition of the hydrotropic agent sodium benzoate, and that solubility increased with more increase in the concentration of the hydrotropic agent.