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Investigate the production of afucosylated IgG antibodies in response to enveloped viruses and evaluate their link to severe COVID-19 outcomes.

December 23, 2020ScienceOpen Access

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

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Authors

MLMads Delbo LarsenUtrecht University EGErik L. de GraafNoldus Information Technology MSMyrthe E. SonneveldUniversity of Amsterdam

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Implication

Observational study reveals afucosylated IgG elevates inflammatory cytokines in severe COVID-19 patients, indicating antibody glycosylation drives severe enveloped virus pathology.

Key Points

Investigate the production of afucosylated IgG antibodies in response to enveloped viruses and evaluate their link to severe COVID-19 outcomes.
Analyzed IgG-Fc N-linked glycan profiles across diverse antigenic exposures to determine the specificity of afucosylated variants.
Assessed SARS-CoV-2-specific afucosylated IgG concentrations and FcγRIIIa-driven cytokine responses in patients with mild versus critically ill COVID-19.
Afucosylated IgG constitutes roughly 6% of total human IgG and is elicited specifically by enveloped viruses rather than non-enveloped viral or other antigens.
Critically ill COVID-19 patients displayed elevated titers of afucosylated anti-SARS-CoV-2 IgG, which strongly bound FcγRIIIa and amplified hyperinflammatory cytokine release and acute phase responses compared to patients with mild disease.

Cite This Study

Larsen et al. (2020) studied this question.

synapsesocial.com/papers/6aaa37994e082451c833b07b https://doi.org/10.1126/science.abc8378

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Implication

Observational study reveals afucosylated IgG elevates inflammatory cytokines in severe COVID-19 patients, indicating antibody glycosylation drives severe enveloped virus pathology.

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

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Implication

Key Points

Cite This Study

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Discussion

Member takes

Implication

Key Points

Cite This Study

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