Four enantiomeric pairs of spirolactones were obtained in a four step synthesis from (+) and (−) limonene. The Claisen rearrangement and iodolactonization were the key steps of the syntheses presented. The structures of products were confirmed by X-ray crystallography of 11, 18b, and 19.
No takes yet. Share an insight, caveat, or question.
Paruch et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: