Key result
This is a study protocol for a randomized controlled trial evaluating the efficacy of home-based exercise prehabilitation to improve postoperative functional outcomes in frail older adults undergoing cancer surgery; results are pending.
Why the study?
Perioperative enteral nutrition and immunonutrition have been increasingly recognized for their benefits in patients undergoing gastrointestinal surgery, but comprehensive data on their role in rehabilitation and prehabilitation are needed.
Does perioperative nutritional support improve outcomes in patients undergoing gastrointestinal surgery?
RCT (n=200)
Single-blind
Permuted blocks of randomly varying lengths, stratified
No
Does perioperative nutritional support improve outcomes in patients undergoing gastrointestinal surgery?
Systematic perioperative nutritional support, including prehabilitation, offers significant benefits for patients undergoing major digestive surgery and should be standard clinical practice.
May support perioperative nutrition in GI surgery; leaves open confirmation by randomized trials.
Continuously increasing reports in the international medical literature, along with current guidelines from international societies, support the view that perioperative enteral nutrition (EN) and immunonutrition offer significant benefits to patients with benign and/or malignant digestive disorders, including reduction of postoperative infections and hospital stay. A vital component of the rehabilitation of patients after major gastrointestinal surgery is a comprehensive nutritional rehabilitation program. It has been shown that implementing an integrated nutritional support program significantly improves patients’ immune responses, accelerates wound healing processes, reduces pain and accompanying anxiety, and decreases hospital length of stay. It appears that, in addition to the efforts of rehabilitation, prehabilitation, i.e. the return to the presurgery level of physical fitness, is or should be a vital objective of the team responsible for rehabilitating patients undergoing gastrointestinal surgery. The present review summarized the most up-to-date data on the role of perioperative nutritional support (EN and immune EN) in the rehabilitation and prehabilitation of patients undergoing major digestive surgery. Systematic and comprehensive perioperative nutritional support for these patients should become a daily clinical practice element of paramount importance.
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John K. Triantafillidis (2025) conducted an RCT in Frailty in patients undergoing elective cancer surgery (n=200). Home-based exercise prehabilitation vs. Standard care plus WHO activity pamphlet was evaluated on 6 min walk test (6-MWT) at the first postoperative clinic visit. This is a study protocol for a randomized controlled trial evaluating the efficacy of home-based exercise prehabilitation to improve postoperative functional outcomes in frail older adults undergoing cancer surgery; results are pending.
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