Very low error rates of NGS-based HLA typing at stem cell donor recruitment question the need for a standard confirmatory typing step before donor work-up

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for severe blood diseases. According to the EBMT activity survey, unrelated stem cell donors provided 52% of all allogeneic stem cell products in 2015 [ 1 ]. Unrelated donor registries inform, recruit and administer potential donors and have built up a global pool of currently more than 32 million donors since the 1970s [ 2 ].