OBJECTIVE: To investigate the effect of exogenous Apelin on pulmonary artery hypertension (PAH) and its related mechanism. METHODS: 62 and Beclin-1 in lung tissues was measured by RT-PCR, and the protein expressions of LC3, LC3-Ⅱ/LC3-Ⅰ, P62 and Beclin-1 in lung tissues were measured by Western blot. RESULTS: <0.05, compared with the Model group). CONCLUSION: Exogenous Apelin has a certain preventive and therapeutic effect on the formation of PAH, and the mechanism may be related to its inhibition effect on autophagy.
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Gou et al. (2020) studied this question.