Key result
HPV vaccination linked to two fully resolved cases of acute disseminated encephalomyelitis.
Why the study?
Cases of acute disseminated encephalomyelitis (ADEM) following human papilloma virus (HPV) vaccination have been reported but require further data accumulation.
Case Report (n=2)
This report highlights two cases of ADEM temporally associated with HPV vaccination, emphasizing the need for further data collection on this potential adverse event.
These cases are hypothesis-generating for ADEM after HPV vaccination; leaves open causality and does not change practice.
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.
No takes yet. Share an insight, caveat, or question.
Sekiguchi et al. (2016) conducted a case report in Acute disseminated encephalomyelitis (ADEM) (n=2). Human papilloma virus (HPV) vaccination was evaluated on Development and resolution of acute disseminated encephalomyelitis. Two adolescent girls developed acute disseminated encephalomyelitis 14 and 16 days after receiving their second dose of human papilloma virus vaccination, with both cases resolving completely.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: