Key result
Dedifferentiated components at the resection margin are linked to worse LRFS in retroperitoneal dedifferentiated liposarcoma.
Why the study?
It was hypothesized that the presence of the dedifferentiated component at the resection margin in retroperitoneal dedifferentiated liposarcoma is associated with adverse outcome.
Does the presence of a dedifferentiated component at the resection margin worsen local recurrence-free survival or overall survival in patients with retroperitoneal dedifferentiated liposarcoma?
Cohort
No
Does the presence of a dedifferentiated component at the resection margin worsen local recurrence-free survival or overall survival in patients with retroperitoneal dedifferentiated liposarcoma?
The presence of a dedifferentiated component at the resection margin in retroperitoneal dedifferentiated liposarcoma is a significant prognostic factor for worse local recurrence-free survival.
Answers are grounded in this paper and cite their sources.
May aid prognostic counseling after resection; leaves open whether dedifferentiated margins warrant intensified local therapy.
OBJECTIVES: We aimed to test the hypothesis that in retroperitoneal dedifferentiated liposarcoma (DDLS) the presence of the dedifferentiated (DD) component at the resection margin is associated with adverse outcome. METHODS: We retrospectively searched the archive for primary resections of retroperitoneal DDLS performed at our institution between 1990 and 2017. Slides were rereviewed for diagnosis, Fédération Nationale des Centres de Lutte Contre le Cancer grade, myogenic differentiation, and the presence of the well-differentiated (WD) or DD component at the resection margin. The medical records were reviewed for patient age, sex, tumor size, tumor focality, adjuvant/neoadjuvant therapy, local recurrence, distant metastases, local recurrence-free survival (LRFS), overall survival (OS), and follow-up duration. RESULTS: The presence of the DD component at the resection margin was associated with worse LRFS compared with cases without the DD component at the margin (P = .002). However, OS was not significantly affected (P = .11). CONCLUSIONS: LRFS is significantly shorter in cases with the DD component at the margin compared with cases without DD tumor at the margin, while there is no association with OS. We recommend reporting the presence or absence of DD tumor at the margin in retroperitoneal DDLS, as it adds meaningful prognostic information.
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Dehner et al. (2021) conducted a cohort in Retroperitoneal dedifferentiated liposarcoma. Presence of dedifferentiated (DD) component at the resection margin vs. Absence of dedifferentiated (DD) component at the resection margin was evaluated on Local recurrence-free survival (LRFS) (p=.002). The presence of a dedifferentiated component at the resection margin in retroperitoneal dedifferentiated liposarcoma was associated with worse local recurrence-free survival (P = .002).
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