Key result
Progressive structural changes in cardiac hypertrophy correlate with evolving functional alterations.
Why the study?
Detailed description of progressive structural changes in cardiac hypertrophy muscle cells is needed to understand their functional significance.
Key points are not available for this paper at this time.
Design
Review examining structural and functional correlations in cardiac hypertrophy
May aid clinical monitoring of hypertrophy progression; leaves open prospective validation in cohorts.
Cardiac hypertrophy involves not only an increase in heart size but progressive, initially subtle, structural changes in muscle cells. The ability to describe these changes in detail has contributed greatly to our understanding of their possible functional significance. Structural and functional correlations in the evolving progression of cardiac hypertrophy are examined.
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Victor J. Ferrans (1983) studied this question. Cardiac hypertrophy involves progressive structural changes in muscle cells that correlate with functional alterations as the condition evolves.
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