Key result
Future antihypertensive therapies target RAAS inhibition via angiotensin II receptors, neutral endopeptidase, and renalase.
Why the study?
Despite progress in treatment, a number of people with uncontrolled or resistant hypertension increases, and new approaches to antihypertensive therapy are needed.
This review highlights emerging therapeutic targets for arterial hypertension, particularly focusing on novel modulators of the renin-angiotensin-aldosterone system.
New strategies for resistant hypertension merit exploration; leaves open efficacy and adherence questions pending randomized data.
Arterial hypertension (HT) takes leading position in the structure of morbidity and mortality among the cardiovascular diseases in the economically developed and developing countries of the world. Despite progress in treatment of this disease, a number of people with uncontrolled or resistant HT increases. There is a problem of inefficiency of therapy or lack of patients' adherence to treatment. Therefore, search for new approaches to treatment of HT continues. Current most effective agents for blood pressure control, and possible future antihypertensive agents, are related to groups of agents, which inhibit renin–angiotensin–aldosterone system (RAAS). Novel targets for antihypertensive therapy could include the angiotensin II type 2 and type 1 receptor , neutral endopeptidase, aldosterone synthase, renalase, endothelin receptors, (pro)renin receptors, vaccine against RAAS components. Development of novel agents and approaches to HT therapy is discussed.
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Popov et al. (2012) conducted a review in Arterial hypertension. Antihypertensive therapy targeting RAAS and novel targets was evaluated. Current and future antihypertensive therapies focus on inhibiting the renin-angiotensin-aldosterone system, with novel targets including angiotensin II receptors, neutral endopeptidase, and renalase.
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