Massively parallel sequencing of cancer genomes is revealing a panoramic view of the genetic drivers of human neoplasms. In this issue of the Journal, Wang et al.1 describe an analysis of the coding sequences of samples from 91 patients with chronic lymphocytic leukemia. The disease is characterized by the accumulation of mature B lymphocytes, and its genetic basis is being rapidly elucidated.2,3 Wang et al. leveraged the large number of samples studied to identify sets of genes that are critical to the development of chronic lymphocytic leukemia. By sequencing both the malignant lymphocytes (CD19+CD5+) and matched nonmalignant control DNA . . .
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Ebert et al. (2011) studied this question.
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