CT-Guided Microwave Thermal Ablation and Cementoplasty as a Part of the Management of Appendicular Osteosarcoma in a Dog

Case Report : The combination of local control and adjuvant chemotherapy is considered the standard of care for appendicular osteosarcoma in dogs. The objective of this case-report was to describe the feasibility and the clinical outcome of a dog with stage-1 osteoblastic appendicular osteosarcoma treated with the combination of microwave ablation (MWA) and cementoplasty. During the procedure, a 14-gauge MWA antenna (ceramic, 200 mm, ECO system) was inserted using computed tomography (CT) guidance in the lesion of the left distal radius. Three ablation cycles of 5 minutes (60 W) were performed using a Saberwave ECO-200G generator (frequency 2,45 GHz). Following the MWA procedure, the bone substitute was injected to consolidate the ablated zone. Adjuvant chemotherapy consisting in six doses of carboplatin, and an autologous vaccine were prescribed. Response was evaluated according to RECIST criteria by CT evaluation at 2 months and at 7 months after the initial treatment. Results showed that 24 hours after MWA, the dog was pain-free and no side effects of the treatment as identified. As well, CT measurements revealed a decreased by 13 and 25% of the longest diameter of the osteolytic lesion at 2 and 7 months respectively, corresponding to stable disease according to RECIST criteria. Even if a pathologic fracture of the treated area was diagnosed three months after the MWA, the quality of life of the dog remains excellent. In conclusion, the combination of MWA and cementoplasty could potentially represent a new limb-sparing option, as a part of multimodal management of appendicular osteosarcoma in dogs. Proprietary/Conflict of Interest : For this case, BIOCERA-VET OSA was provided free of charge by the company TheraVet. Publication History Article published online: 11 September 2023 © 2023. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany