Cardiac arrest management in the 2025 AHA guidelines: algorithmic changes and clinical practice recommendations

The 2025 American Heart Association (AHA) guidelines include significant changes in cardiac arrest management. This review aims to evaluate the major modifications introduced by the new guidelines from an evidence-based medicine perspective. The expansion of indications for mechanical cardiopulmonary resuscitation (CPR), the use of capnography as a prognostic marker, the integration of artificial intelligence-assisted decision systems, and personalized post-resuscitation care protocols are among the prominent innovations. In light of randomized controlled trials and meta-analyses, these changes have the potential to achieve a significant reduction in in-hospital cardiac arrest mortality.