Key result
High neutrophil-to-lymphocyte ratio links to >6% predicted five-year SCD risk in HCM patients.
Why the study?
The predictive value of the neutrophil-to-lymphocyte ratio (NLR) in hypertrophic cardiomyopathy (HCM) patients regarding echocardiographic, electrocardiographic parameters, and five-year sudden cardiac death risk was unclear.
Is the neutrophil-to-lymphocyte ratio associated with echocardiographic and electrocardiographic parameters, and predicted five-year risk of sudden cardiac death in patients with hypertrophic cardiomyopathy?
Observational (n=171)
Is the neutrophil-to-lymphocyte ratio associated with echocardiographic and electrocardiographic parameters, and predicted five-year risk of sudden cardiac death in patients with hypertrophic cardiomyopathy?
A higher neutrophil-to-lymphocyte ratio is associated with adverse electrocardiographic features and a higher predicted five-year risk of sudden cardiac death in patients with hypertrophic cardiomyopathy.
INTRODUCTION: Previous studies have demonstrated the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in many cardiovascular disorders. The aim of this study was to assess whether NLR is associated with echocardiographic or electrocardiographic parameters, or with predicted five-year risk of sudden cardiac death (SCD), in patients with hypertrophic cardiomyopathy (HCM). METHODS: This prospective observational study included 74 controls and 97 HCM patients. Three years of follow-up results for HCM patients were evaluated. RESULTS: NLR was significantly higher in patients with fragmented QRS, ventricular tachycardia, and presyncope than in those without (p=0.031, 0.030, and 0.020, respectively). NLR was significantly higher in patients whose predicted five-year risk of SCD was more than 6% and whose corrected QT interval was greater than 440 ms (p=0.022 and 0.001, respectively). It was also significantly higher in patients whose left ventricular ejection fraction (LVEF) was <60% than in those with LVEF >60% (p=0.017). CONCLUSION: NLR was significantly higher in patients with HCM compared to the control group. A high NLR is associated with a higher five-year risk of SCD in patients with HCM.
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Özyılmaz et al. (2017) conducted an observational in hypertrophic cardiomyopathy (n=171). Neutrophil-to-lymphocyte ratio (NLR) vs. Control group / lower NLR was evaluated on Predicted five-year risk of sudden cardiac death (SCD) >6% (p=0.022). A high neutrophil-to-lymphocyte ratio was significantly associated with a predicted five-year risk of sudden cardiac death >6% (p=0.022) in patients with hypertrophic cardiomyopathy.
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