Analysis of injectable drugs (Pentazocine and Diazepam) sampled from shops and companies in Anambra State, Nigeria

The incidences of drug adulteration and drug resistance have been a major problem facing mankind in recent years. Low and medium-income countries like Nigeria are most affected. An investigation was carried out to determine the quality of Pentazocine and Diazepam injections in circulation in Anambra State. The injections were sampled from different markets, shops, and pharmaceutical companies within the State. Imported and locally manufactured brands of the injections were analysed. Identification, pH, Assays, Bacteria Endotoxin, sterility, and sub-visible particulate matter contamination were analysed. The results of the Identification, Bacteria Endotoxin (BET), Particulate matter count, and pH are all within the British Pharmacopeia. The Pentazocine Assays obtained were (98.31%- 102.5%) which are within the British Pharmacopeia limit of (95% – 105%). This is good for health management. The Assays of two of the Diazepam injections tested were between (111.33% - 111.53%), which is above the approved British Pharmacopeia limit of (90%-110%). This is an indication of high level of impurities and not good for health care management.