Key result
IV morphine lowers cardiac work ~8% in CAD patients while pentazocine increases it.
Why the study?
The differing hemodynamic effects of morphine and pentazocine in patients with coronary-artery disease required direct comparison to guide analgesic choice based on cardiovascular status.
Does intravenous morphine compared to intravenous pentazocine have different hemodynamic effects in patients with coronary artery disease?
Population
17 patients with arteriographically proved coronary-artery disease
Comparison
8 mg intravenous morphine vs 48 mg intravenous pentazocine
Design
Randomized double-blind trial
Authors
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May favor morphine over pentazocine for analgesia in CAD to reduce cardiac work; confirms opposing hemodynamic effects in RCT.
RCT (n=17)
Double-blind
Randomized
Does intravenous morphine compared to intravenous pentazocine have different hemodynamic effects in patients with coronary artery disease?
Morphine and pentazocine have opposing hemodynamic effects in patients with coronary artery disease, with morphine decreasing and pentazocine increasing cardiac work.
Alderman et al. (1972) conducted an RCT in Coronary-artery disease (n=17). Morphine vs. Pentazocine (48 mg intravenously) was evaluated on Hemodynamic effects including cardiac work. Intravenous morphine decreased cardiac work by 8.2%, whereas pentazocine increased cardiac work by 22.1% in patients with coronary artery disease.
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