Key result
Oral esproquin increases cardiac output and stroke volume in normal volunteers via positive inotropic effects.
Why the study?
The effects of oral esproquin on cardiac inotropy and hemodynamics in normal subjects were not previously characterized.
Does single-dose oral esproquin improve hemodynamic parameters in normal volunteers?
Does single-dose oral esproquin improve hemodynamic parameters in normal volunteers?
Oral esproquin produces a sustained positive inotropic effect in normal volunteers, suggesting potential utility for the treatment of chronic heart failure.
Hypothesis-generating for heart failure therapy; prospective patient trials needed before any clinical consideration.
The Hypertension and Glinical Hemodynamics Section, Veterans Administratian Hospital, and the Department of Medicine, Georgetown University School of Medicine An isoquinoline derivative, esproquin (NG 7197), was administered in single oral doses of 100, 200, or 300 mg to 15 normal volunteers. A dose‐related positive inotropic effect was characterized by an increase in cardiac output and stroke volume that persisted for about 4 hours without a significant change in heart rate associated with areduction in pre‐ejection period and an increase in mean systolic ejection rate. Arterial pressure rose with the lower doses, but diastolic press ure fell and forearm blood flow increased with the highest dose. These data indicate that oral administration of esproquin produces a sustained positive inotropic effect and that in Zarger doses peripheral vasodilatation results either from adrenergic blockade or a direct vascular effect. The drug deserves evaluation for the treatment of chronic heart failure.
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Kotelanski et al. (1973) studied Healthy volunteers (n=15). Esproquin (NG 7197) was evaluated on Positive inotropic effect (cardiac output and stroke volume). Oral administration of esproquin produced a sustained, dose-related positive inotropic effect characterized by increased cardiac output and stroke volume in normal volunteers.
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