Key result
Oleoylethanolamide induces visceral pain and reduces food intake in mice via TRPV1.
Why the study?
The mechanisms by which oleoylethanolamide excites vagal sensory afferent neurones to regulate feeding and body weight are unclear.
Population
Wild-type and TRPV1-null mice and cultured nodose ganglion neurones
Comparison
Oleoylethanolamide administration vs TRPV1-null mice/neurones or capsazepine treatment
Design
Preclinical experimental study
Authors
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TRPV1 mediates OEA effects on visceral pain and feeding in mice; leaves open human translation and clinical relevance.
The acute behavioral effects of OEA, including reduced food intake and visceral pain, are mediated via activation of the TRPV1 receptor.
Miyares et al. (2005) studied this question. Oleoylethanolamide (OEA) vs. TRPV1-null mice / capsazepine was evaluated on visceral pain-related behaviours and food intake. Oleoylethanolamide administration induced visceral pain-related behaviours and reduced 30-minute food intake in wild-type mice, effects that were absent in TRPV1-null animals.
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