Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

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The active metabolite of aeruginascin binds with high affinity to human serotonin receptors 5-HT1A, 5-HT2A, and 5-HT2B, but lacks the previously predicted binding activity at the 5-HT3 receptor. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

A.R. Chadeayne; Duyen N. K. Pham; Brian G. Reid; James A. Golen; David R. Manke

doi:10.1021/acsomega.0c02208

July 2, 2020ACS OmegaOpen Access

Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

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Abstract

High Resolution Image Download MS PowerPoint Slide The putative active metabolite of aeruginascin, a naturally occurring tryptamine of “magic mushrooms,” has been synthesized and structurally characterized. Competitive radioligand binding assays demonstrate that it has a high affinity at human serotonin receptors 5-HT 1A, 5-HT 2A, and 5-HT 2B, though it does not bind at the 5-HT 3 receptor, where activity was previously predicted.

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Chadeayne et al. (2020) studied this question.

synapsesocial.com/papers/6aaa6537eefabf3dbb08645a https://doi.org/10.1021/acsomega.0c02208

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Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

Abstract

Discussion

Cite This Study

Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

Abstract

Discussion

Cite This Study

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