During all developmental stages of female puberty (P i -P j ) plasma LH and FSH concen- tration determined by radioimmunoassay decreased after a single i.m. injection of 50 ygfkg estradiol-dipropionate in oil.This decrease coincidenced with the peaking level of circulating estradiol (measured by radioimmunoassay).Only in the group of girls in an advanced stage of puberty (premenarche P 4 ) this initial nadir was followed by a secondary increase in plasma LH concentration but not in that of FSH.This secondary increase occurred during the period of decreasing level of circulating estradiol.However, only in two of the five girls at this advanced stage of puberty (P 4 ) the maximum of plasma LH approached the value of the preovulatory plasma LH peak in adult women.These results suggest that the potential for a stimulatory (positive) estrogen feedback response appears after mid- puberty at the stage P 4 . ------
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Presl et al. (1976) studied this question.
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