Serum concentrations of IgM and IgG antibodies in patients with Mycoplasma pneumoniae pneumonia were determined by means of the enzyme-linked immunosorbent assay. Analysis of serum specimens by treatment with protein A followed by fractionation on sucrose density gradient revealed for the first time the presence of rheumatoid factor in M. pneumoniae pneumonia with a remarkably high frequency. Development and persistence of the rheumatoid factor during the clinical course of this disease were also examined.
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Mizutani et al. (1983) studied this question.