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OBJECTIVE: To assess the effect of tranexamic acid (TXA) use in hip fracture surgery. METHODS: A retrospective cohort study was performed using the Premier Healthcare database. A propensity score matching approach was applied to assess associations between TXA use and blood transfusion, perioperative complications, length of stay (LOS), and hospitalization cost. RESULTS: In 153,169 patients, TXA use was associated with a 17% decrease in odds of blood transfusion, no increase in the risk of perioperative complications, 16% shorter LOS, and minimal effects on hospitalization cost. CONCLUSION: Our results are in support of a wider use of TXA in hip fracture surgery. LEVEL OF EVIDENCE: Level III.
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Cheung et al. (2020) studied this question.
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