Key result
Uncoupled NOS activity, rather than Nox activation, generates reactive oxygen species and hydrogen peroxide in calcifying human aortic valves.
Highlights the role of NOS uncoupling and hydrogen peroxide in aortic valve calcification, suggesting new targets for prevention.
Arterial calcification increasingly afflicts our aging populace ([1][1]). Approximately 2% of individuals over age 65 years will require aortic valve replacement (AVR) for calcific aortic stenosis ([1][1]). On the basis of recent epidemiologic studies ([2][2]), the increasing prevalence of metabolic
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Dwight A. Towler (2008) conducted an editorial in Aortic valve calcification. NOS uncoupling was evaluated. Uncoupled NOS activity, rather than Nox activation, generates reactive oxygen species and hydrogen peroxide in calcifying human aortic valves.
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