Key result
BPA markedly reduces mPAP to near normal despite persistent pulmonary microvascular remodeling.
Why the study?
Histology of the pulmonary vasculature following balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension had not been reported.
What are the histological changes in the pulmonary vasculature following balloon pulmonary angioplasty in a patient with chronic thromboembolic pulmonary hypertension?
Case Report (n=1)
What are the histological changes in the pulmonary vasculature following balloon pulmonary angioplasty in a patient with chronic thromboembolic pulmonary hypertension?
This first histological report following BPA for CTEPH demonstrates that despite marked hemodynamic improvement, intimal thickening and luminal stenosis persist in the pulmonary microvasculature.
Pulmonary arterial lesions in CTEPH may be diffuse despite BPA; this case leaves open questions on procedural impact on histology.
We herein report a case of peripheral type chronic thromboembolic pulmonary hypertension treated with medical therapy and subsequent balloon pulmonary angioplasty (BPA). After a series of BPA procedures, the patient's hemodynamics almost completely normalized. The patient was later diagnosed with lung carcinoma, and the vasculature of the resected lung demonstrated intimal thickening and luminal stenosis in the pulmonary arteries in both the areas where BPA was performed and not performed, in spite of a marked reduction in pulmonary arterial pressure. The present case is the first report on the histology of the pulmonary vasculature following BPA.
No takes yet. Share an insight, caveat, or question.
Ogawa et al. (2014) conducted a case report in Chronic Thromboembolic Pulmonary Hypertension (n=1). Balloon pulmonary angioplasty was evaluated on Hemodynamics (mean pulmonary arterial pressure) and histological pulmonary microvascular remodeling. Balloon pulmonary angioplasty markedly reduced mean pulmonary arterial pressure to near normal levels, despite persistent histological evidence of pulmonary microvascular remodeling in both treated and untreated areas.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: