The MMRpro model accurately predicted the probability of carrying a cancer-susceptibility gene mutation for the Lynch syndrome

Clinical Prediction GuideMarch 1, 2007The MMRpro model accurately predicted the probability of carrying a cancer-susceptibility gene mutation for the Lynch syndromeDeborah Terespolsky, MDDeborah Terespolsky, MDCredit Valley Hospital, Mississauga, Ontario, Canada (D.T.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2007-146-2-053 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationChen S, Wang W, Lee S, et al. Prediction of germline mutations and cancer risk in the Lynch syndrome. JAMA. 2006;296:1479-87. https://pubmed.ncbi.nlm.nih.gov/17003396Clinical Impact RatingsGastroenterology: Genetics: Oncology: References1 Balmaña J, Stockwell DH, Steyerberg EW, et al. Prediction of MLH1 and MSH2 mutations in Lynch syndrome. JAMA. 2006;296:1469-78. [PMID: 17003395] Google Scholar2 Barnetson RA, Tenesa A, Farrington SM, et al. Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer. N Engl J Med. 2006;354:2751-63. [PMID: 16807412] Google Scholar Author, Article, and Disclosure InformationAffiliations: Credit Valley Hospital, Mississauga, Ontario, Canada (D.T.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails March 1, 2007Volume 146, Issue 2Page: 53KeywordsAdenomasAlgorithmsBayesian methodCancer geneticsCancer immunotherapyClinical geneticsColorectal cancerDNAForecastingGeneticsGermline mutationHereditary nonpolyposis colorectal cancerMismatch repairMutation detectionOvarian cancerStainingSurgery ePublished: 9 March 2020 Issue Published: March 1, 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...