What, where, and when: the importance of post-transcriptional regulation in the brain

The last decade marked an expansion of genome-wide exper-imental and computational techniques that provide unprece-dented insights into the mechanisms and physiological relevance of post-transcriptional regulation in the brain, and how it can go awry in disease (Darnell, 2013; Modic et al., 2013). The new methods enable to study protein-RNA and miRNA-RNA inter-actions with high specificity and positional resolution (Gascon and Gao, 2012; Konig et al., 2012). Moreover, the development of RNAseq, ribosome profiling and related emerging functional genomic and computational methods, has enabled global stud-ies of alternative splicing, RNA editing, methylation, stability and