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A new synthetic route to aminomethylpsoralens, substituted on the furan‐ring, has been developed by electrophilic substitution of N‐hydroxymethylphthalimide and subsequent hydrazinolysis. Hydroxy and methoxy activating functions on the psoralens lead to multi‐site substitution and the products of these phthalimido‐methylations resist simple cleavage with hydrazine. The two‐step introduction of a single CH2NH2 group is successful in psoralens containing only methyl substituents.
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Heindel et al. (1985) studied this question.
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